AUTOR/ES: N. Franklin Adkinson, Jr., MD, John W. Yunginger, MD, William W. Busse, MD, Bruce S. Bochner, MD, F.
ISBN: 9780323014250
AÑO: 2003
EDICION: 6ª
IDIOMA: Inglés
ENCUADERNACIÓN: Book With Online E-dition, Reference
PÁGINAS: 1746
DIMENSIONES: 216 X 276 mm
FIGURAS: Illustrated
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RELACIONADOS: Allergy & Clinical Immunology
PUNTOS CLAVE: This new 6th Edition carries on the long-standing tradition of excellence that has earned Middleton's Allergy: Principles and Practice a worldwide reputation as the leader in its field. Focusing on human immunology and biology, while also reporting on relevant animal experimentation, it provides comprehensive coverage of state-of-the-art basic science as well as authoritative guidance on the practical aspects of day-to-day diagnosis and management. An international group of editors and contributors, ranking amongst the world's most noted authorities in allergy, have comprehensively updated this new edition to incorporate all of the very latest advances in scientific and clinical knowledge. Also now included FREE is the Adkinson e-dition, a website that gives you: All of book's contents online, fully searchableRegular updates to the content, keeping you contantly up-to-dateA complete library of easily downloadable electronic imagesLinks to key allergy websitesPatients handouts... and more! KEY FEATURES Equips you with state-of-the-art, evidence-based guidance to help you offer your patients the best possible outcomes.Includes 500 outstanding illustrations that clarify all essential concepts and capture the appearance of important presenting signs.Uses highly structured, full-color page layouts inside the printed book to make reference effortless.Offers rapid access to the answers you need via the fully searchable web site.Delivers regular updates online, overseen by the authors, to keep you continually apprised of important new clinical developments.Lets you download all of the book's illustrations for use in electronic presentations.Links references to the corresponding MEDLINE abstracts to simplify further research.Includes review questions to facilitate self-assessment. NEW TO THIS EDITION Offers brand-new coverage of aerobiology of outdoor allergens · indoor and outdoor air pollution · allergy vaccines · antigen presentation and immunoregulation · and many other topics!Presents fresh perspectives from 3 new editors and a multitude of new contributors.
INDICE: Section A: Immunology 1: The Immune System: An Overview 2: Molecular Biology and Genetic Engineering 3: Principles and Application of Genetics 4: Genetics of Allergic Disease and Asthma 5: Immunoglobulin Structure and Function 6: The Complement System 7: Synthesis and Regulation of Immunoglobulin E 8: Signal Transduction 9: Cellular Adhesion in Inflammation 10: Cytokines in Allergic Inflammation 11: Chemokines in Cell Movement and Inflammation 12: Antigen Presentation and Immunoregulation 13: Mast Cell-Derived Mediators 14: Lipid Mediators of Hypersensitivity and Inflammation 15: Neuronal Control of Airway Function in Allergy 16: Biochemical Events in Basophil or Mast Cell Activation and Mediator Release 17: Biology of Lymphocytes 18: Biology and Role of Neutrophils in Asthma 19: Biology of Eosinophils 20: Biology of Mast Cells 21: Biology of Basophils 22: Biology of Monocytes and Macrophages 23: Biology of Epithelial Cells 24: Biology of Endothelial Cells 25: Biology of Airway Smooth Muscle Cells 26: Apoptosis of Inflammatory Cells 27: Delayed-Type Hypersensitivity and Cellular Immunity: Effector/Regulator Molecules and Mechanisms 28: Allergic Inflammation: Initiation, Progression, and Resolution 29: Animal Models of Asthma 30: Pathophysiology of Allergic Inflammation 31: Immunopathology of Allergic Airway Inflammation Section B Aerobiology and Diagnosis of Allergy 32: Air Pollution: Indoor and Outdoor 33: Aerobiology Outdoor Allergens 34: Indoor Allergens 35: Preparation and Standardization of Allergen Extracts 36: Allergen Structure and Function 37: Methods in Laboratory Immunology 38: In Vivo Methods for Study of Allergy: Skin Tests, Techniques, and Interpretation 39: Nasal Provocation Testing 40: Bronchial Challenge Testing Section C Physiology 41: Structural and Functional Cutaneous Immunology 42: Immunologic and Nonimmunologic Lung Defense Mechanisms 43: Structure and Function of Airway Smooth Muscles 44: Development, Structure, and Physiology in Normal and Asthmatic Lung 45: Airway Mucus and the Mucociliary System 46: Aerosols 47: Anatomy and Physiology of the Nose and Control of Nasal Airflow Section D Pharmacology 48: Principles of Pharmacotherapeutics 49: Beta-Adrenergic Agonists 50: Theophylline and Phosphodiesterase Inhibitors 51: Antihistamines 52:Glucocorticosteroids A) Mechanisms of Action in Allergic Diseases B) Clinical Use 53: The Chromones: Cromolyn Sodium and Nedocromil Sodium 54: Cholinergic Mechanisms and Anticholinergic Therapy in Respiratory Diseases 55: Antileukotriene Therapy in Asthma 56: Immunomodulators Section E Clinical Science 57: Cell-Mediated Immunity in Health and Disease 58: Immune Complexes and Allergic Disease 59: Primary Immunodeficiency Diseases 60: Approach to the Patient with Recurrent Infections 61: Immunology of HIV Infection and Its Relationship to Allergic Diseases 62: Clinical Significance of IgE 63: Eosinophilia and Easinophil-Related Disorders 64: Epidemiology of Asthma and Allergic Diseases 65: Allergic Disease in Childhood A) Natural History, Development, and Prevention B) Early Childhood Correlates of Allergic Disease 66: Asthma: Definition and of Allergic Disease in Pathogenesis 67: Pathology of Asthma Compared with Chronic Obstructive Pulmonary Disease 68: Asthma in Infancy and Childhood 69: Asthma in Adults: Evaluation and Management 70: Asthma Guidelines and Outcomes 71: Asthma and Allergic Diseases During Pregnancy 72: Exercise-Induced Airway Narrowing 73: Occupational Asthma 74: Allergic Bronchopulmonary Aspergillosis 75: Hypersensitivity Pneumonitis 76: Allergic and Nonallergic Rhinitis 77: Endoscopy of the Upper Airway 78: Nasal Polyps and Sinusitis 79: Otitis Media 80: Immunotherapy for Inhalant Allergens 81: Insect Allergy 82: Natural Rubber Latex Allergy 83: Anaphylaxis and Anaphylactoid Reactions 84: Mastocytosis Syndromes 85: Urticaria and Angioedema 86: Atopic Dermatitis 87: Contact Dermatitis 88: Allergic and Immunologic Disorders of the Eye 89: Adverse Reactions to Foods 90: Adverse Reactions to Food and Drug Additives 91: Adverse Reactions to Vaccines 92: Drug Allergy - Appendix A Chemokines - Appendix B Adhesion Molecules - Appendix C Leukocytes - Appendix D Internet sites
DATOS DEL AUTOR: By N. Franklin Adkinson, Jr., MD, Professor of Medicine and Training Program Director, Division of Allergy and Clinical Immunology, The Johns Hopkins Asthma and Allergy Center, The Hopkins Bayview Medical Campus, Baltimore, Maryland; John W. Yunginger, MD, Emeritus Consultant in Pediatrics and Internal Medicine (Allergy), Mayo Clinic and Foundation; Emeritus Professor and Pediatrics, Mayo Medical School, Rochester, Minnesota; William W. Busse, MD, Professor of Medicine, University of Wisconsin Hospital and Clinics; Head, Allergy and Clinical Immunology, Department of Medicine, University of Wisconsin School of Medicine, Madison, Wisconsin; Bruce S. Bochner, MD, Professor of Medicine, The Johns Hopkins Asthma and Allergy Center, The Hopkins Bayview Medical Campus, Baltimore, Maryland; F. Estelle R. Simons, MD, PFCPC, Bruce Chown Professor and Head, Section of Allergy and Immunology, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada; and Stephen T. Holgate, MD, DSc, FRCP, FRCPE, MRC, Clinical Professor of Immunopharmacology, Southampton General Hospital School of Medicine, University of Southampton, Southampton, United Kingdom